• These observations are of particular interest in the context

  2022-06-09

  

  These observations are of particular interest in the context of recent conceptual changes regarding the mechanisms by which different types of leukocytes contribute to atherogenesis. Over the last decade, the paradigm of the predominant circulatory origin of lesional macrophages has been challenged

• The ability of GPX and

  2022-06-09

  

  The ability of GPX4 and other selenoproteins to be selectively induced by ferroptotic stimuli suggests that the stress-induced increase in the transcription of a number of putative, “antioxidant” selenoproteins is an adaptive homeostatic, but insufficient response to prevent cell death in the face o

• Conformational analysis provides further insight into the SA

  2022-06-09

  

  Conformational analysis provides further insight into the SAR trends apparent in . Acyclic precursors – are 25–50-fold less active than their macrocyclic counterparts – against Pyk2. The global minima for – are conformations in which the –NHCH– linker between the pyrimidine and pyridine rings is sta

• NeuroHIV is initiated by HIV crossing

  2022-06-09

  

  NeuroHIV is initiated by HIV crossing the blood–brain barrier (BBB) to enter the CNS. This is thought to occur primarily via the transmigration of infected CD14+CD16+ monocytes (Williams, 2014), using the monocytes as “Trojan Horses” (Peluso, 1985), although some studies suggest alternate routes of

• br The HDC knockout mouse as

  2022-06-08

  

  The HDC knockout mouse as a pathophysiological model of TS The implication of a hypomorphic allele of the Hdc gene as a rare cause of TS (Ercan-Sencicek et al., 2010) created a rare opportunity for the generation of a pathophysiologically grounded model of the disorder. Modeling pathophysiology o

• br Materials and methods br Results br Discussion The major

  2022-06-08

  

  Materials and methods Results Discussion The major findings of the present study are that: 1) the response to inverse agonists may be crossregulated by the activation of either 54011 mg H1 or H2 receptors, 2) histamine H1 and H2 receptor inverse agonists crossdesensitize the receptor´s resp

• Metal organic frameworks MOFs have emerged over the past two

  2022-06-08

  

  Metal–organic frameworks (MOFs) have emerged over the past two decades with the potentials to act as promising materials in gas storage, chemical separation, catalyst, magnetism, sensing, and drug delivery etc (Du et al., 2013, Zhou and Kitagawa, 2014). Additionally, the secondary interactions, such

• In conclusion studies of the regulation of the

  2022-06-08

  

  In conclusion, studies of the regulation of the HO-1/BVR/CO pathway by selective pharmacological approaches may lead to the discovery of novel compounds for the treatment of diverse diseases. Recent results validate the use of advances in targeting HO-1 in various vascular diseases. However, there a

• Though studied less extensively than

  2022-06-08

  

  Though studied less extensively than in cholangiopathies and fatty liver diseases, the Hh pathway is active in other forms of human liver disease, such as Schistosomiasis[58], [101] and chronic viral hepatitis,[100], [125] as well as in several animal models of liver disease, including drug-induced

• Egypt has the highest prevalence of HCV worldwide

  2022-06-08

  

  Egypt has the highest prevalence of HCV worldwide with almost 20% of the population being infected. The HCV subtype 4a belonging to genotype 4 (HCV-4) is the most common genotype in Egypt [25], [26], [27], [28]. The sequence of the NS5A/NS5B junction for the Egyptian genotype 4 is Glu-Asp-Val-Val-Cy

• br Results and discussion GSTP is a

  2022-06-08

  

  Results and discussion GSTP1 is a Phase II cytoprotective and detoxifying enzyme. Due to its role in the detoxification of numerous endogenous and exogenous chemical agents (with electrophilic functional groups), individuals with Ile105Val mutation in this gene show enhanced risk of atopic disord

• Obestatin synthetized mainly in the gastrointestinal tract p

  2022-06-08

  

  Obestatin, synthetized mainly in the gastrointestinal tract, participates in the regulation of metabolic functioning at both central and peripheral levels (food intake, pancreatic activity or/and adipocytes proliferation) (Granata et al., 2008; Li et al., 2011). It is involved in the complex gut-bra

• LPCs have been previously described

  2022-06-08

  

  LPCs have been previously described as potential anti-diabetic factors due to stimulation of secretory activity from the isolated rodent pancreas, L-type cells, ands insulin-producing cell lines, with LPC 18:1 as the main structure of interest (Soga et al., 2005, Sakamoto et al., 2006, Overton et al

• GK also called hexokinase IV or D

  2022-06-08

  

  GK, also called hexokinase IV or D, is a glycolytic enzyme that converts 4E1RCat to glucose-6-phosphate. GK has unique characteristics compared with those of the ubiquitously expressed hexokinase isoforms I–III, and is predominantly expressed in the pancreas and liver. In pancreatic β-cells, GK reg

• br Competing interests br Acknowledgements br Introduction F

  2022-06-08

  

  Competing interests Acknowledgements Introduction - Factors Regulating Glucose Tolerance Strictly speaking, the incretin effect refers to the amplification of insulin secretion, which occurs when Aldicarb is taken in orally as compared to infused intravenously [1]. Normally, the insulin re

16016 records 424/1068 page Previous Next First page 上5页 421422423424425 下5页 Last page