• To verify DNA glycosylase AP lyase activity

  2022-03-12

  

  To verify DNA glycosylase/AP lyase activity we have employed a simple and efficient method to investigate based on fluorescein-labeled duplex oligonucleotides read on an automated sequencer (Allgayer et al., 2013, Lopes et al., 2007, Lopes et al., 2008). This approach using purified CpMutY proteins

• Finally the results in this article indicate

  2022-03-12

  

  Finally, the results in this article indicate that atomistic MD in conjunction with computational electrophysiology and ion-permeation simulations provide a useful tool for the functional annotation of ion-channel structures. In particular, they exemplify how MD simulations in native lipid membranes

• br Acknowledgements This work was supported by

  2022-03-12

  

  Acknowledgements This work was supported by the Science and Technology Department of Hubei Province (No.2016CFB368) and the National Natural Science Foundation of China (No. 81201053). Introduction L-Glutamate (glutamate) is the most important excitatory neurotransmitter of the central nervou

• It is important to control hyperglycaemia because it

  2022-03-12

  

  It is important to control hyperglycaemia because it can contribute to serious complications. Hyperglycaemia can be managed by maintaining stable blood glucose levels inside the normal range. This can be achieved by various strategies such as diet, medications and exercise (O’Keefe & Bell, 2007). Se

• The previous studies focused on the

  2022-03-12

  

  The previous studies focused on the regulation of GK activity by nutrients directly or nutritional hormones (Panserat et al., 2014), there was still a lack of studies paid attention to GK both in activity level and transcriptional level. Besides, the GK regulation by dietary matrix metalloproteinase

• It was previously proposed that glucagon acts in

  2022-03-12

  

  It was previously proposed that glucagon acts in the liver, in which a signal is produced and relayed to the Sulfaphenazole via vagal nerves [8], [36], [37]. The concept that the liver is the primary target site was supported by the studies reporting that the glucagon receptor is localized in the l

• Introduction Glucose dependent insulinotropic polypeptide GI

  2022-03-12

  

  Introduction Glucose-dependent insulinotropic polypeptide (GIP) is a hormone secreted postprandially from enteroendocrine K cells in response to ingestion of either fat [1], protein [2], or carbohydrates [3]. GIP is primarily known for its glucose-dependent insulinotropic actions mediated via the G

• Growth hormone secretagogue receptor GHSR is a member of G

  2022-03-12

  

  Growth hormone secretagogue receptor (GHSR) is a member of G-protein-coupled receptor family [3]. GHSR is predominantly expressed in human pituitary, rhypothalamus and hippocampus [4]. GHSR is also expressed in peripheral tissues including lungs, liver, kidney, and adrenal gland. In cardiovascular s

• Retinal GAL receptor distribution suggests an

  2022-03-12

  

  Retinal GAL receptor distribution suggests an intrinsic neuronal control since retina lacks an autonomic innervation, and a signal modulation seems most likely here, acting via GALR1 while GALR2 and GALR3 seem to play a rather minor role in this signal transduction. While sources acting on these ret

• CTPB Single cell reverse transcriptase PCR on A

  2022-03-12

  

  Single-cell reverse transcriptase-PCR on A. mellifera antennal lobe (AL) cells showed the expression of RDL as well as another GABA receptor like subunit, LCCH3 (Dupuis et al., 2010). Based on whole cell patch-clamp electrophysiology it was concluded that the predominant GABA receptors in AL cells a

• In the phylum Cnidaria which separated from the

  2022-03-12

  

  In the phylum Cnidaria, which separated from the main line of Metazoa early during evolution, FGFR signaling is essential during development and morphogenesis. Two FGFRs and two FGFs antagonistically control formation of the apical organ in the anthozoan Nematostella and target the MAPK pathway (Ren

• br Molecular aberrations in the FGFR signaling pathway br

  2022-03-12

  

  Molecular aberrations in the FGFR signaling pathway Non–small cell lung cancer Small cell lung cancer Integrated Sulfo-NHS-LC-Biotin analysis revealed focal amplification of FGFR1 in 6% of SCLC cases. In another study with PD173074, Pardo et al. used two human SCLC xenograft models, H-510

• br Introduction Isoprenoid structures play an essential

  2022-03-12

  

  Introduction Isoprenoid structures play an essential role in biology and over 30,000 natural products of this class are known (Greenhagen et al., 2003). Like other animals, insects require these compounds for many disparate processes, including electron transport (e.g., ubiquinones), protein glyc

• The effect of combined A and PD treatment on the

  2022-03-11

  

  The effect of combined A-192621 and PD 155080 treatment on the Benzoylhypaconitine during endotoxin infusion is quite different compared to either drug used alone (Wanecek et al., 1999). After administration of both antagonists in combination, cardiac index increased to baseline values within 30 mi

• Despite the two models for the HIV IN aptamer complexes

  2022-03-11

  

  Despite the two models for the HIV-1 IN-aptamer complexes appeared to be comparable, disintegration assays revealed that 93-del inhibited C– or N-terminally truncated enzyme at the same extent, [18] whereas, T30695 required N-terminal domain (NTD) of the enzyme to exert its integrase inhibitory acti

16018 records 473/1068 page Previous Next First page 上5页 471472473474475 下5页 Last page